In women of childbearing age estradiol synthesized in ovarian follicles under the influence of FSH (follicle stimulating hormone), then it is released into the blood.During pregnancy, the hormone is produced in the placenta.In men estradiol synthesized in the testes and adrenal glands.Its role in the functioning of the body less well understood, but we have found that it performs a regulatory function in the process of secretion of gonadotropic hormones.
Approximately 90-98% of the circulating hormone in the body is in a bound state, the rest is its active form called free estradiol.Estradiol stimulates the growth of reproductive organs, the development of secondary sexual characteristics, is involved in the processes of production of gonadotropins.In the normal course
Analysis of blood estradiol
women appointed to determine blood levels of free oestradiol in the therapeutic monitoring of infertility (eg, in vitro fertilization, hormone replacement therapy).When ECO determining the concentration of this hormone is administered daily in order to properly determine the right time to capture the oocyte and receiving hCG - human chorionic gonadotropin.
also define it for the evaluation of ovarian tumors diagnosis.Determining the level of estradiol in serum should be performed for menstrual dysfunction: delayed sexual development in girls, premature sexual development, menopause, amenorrhea (primary and secondary).Normal estradiol levels in healthy women is as follows: in the follicular phase - 30-120 pg / ml, during ovulation - 130-370 pg / ml in the luteal phase - 70-250 pg / ml, in menopause - pg 15-60/ ml.Healthy men estradiol in the serum is 15-60 pg / ml.
Reduced estradiol levels may occur with insufficient function of the corpus luteum, ovarian, and in the absence of ovulation.The increased concentration of estradiol detected in patients with gynecomastia, testicular feminization syndrome, testicular cancer.Determining the concentration of estradiol in the absence of other data will be insufficient for the diagnosis of any disease.The result should be viewed in conjunction with other clinical findings and data analysis of hormonal status.