«Piaskledin" is used in osteoarthritis of the knee and hip joints 1-3 stage (in combination with other drugs), as well as for the treatment of periodontitis.The composition of one capsule means contains: 200 mg of the compounds of unsaponifiable soybean oil, 100 mg of the compounds of unsaponifiable of avocado oil, adjuvants (butylhydroxytoluene, colloidal silicon dioxide).Analogs "Piaskledina", "treatment with artrofoon", "Alflutop", "Osteoartrizin", "Intsena", "Revmafit", "Travmalek", "rumalon", "Phong Thu Thap", "chondroitin ointment."
mechanism of drug action is to correct the exchange of cartilage.The tool has on the affected joints analgesic and anti-inflammatory effects, the recovery of motor function, slows the destruction of cartilage in the joints, reduces pain symptoms.Experimental studies have shown that "Piaskledin" has a regenerative e
ffect on cartilage by stimulating the formation of collagen in joints chondrocytes.
compounds soybean oil and avocado oil help to increase collagen production, strengthen the impact of the transforming growth factor β1 (TGF) in chondrocytes, has anabolic effects.They also reinforce the process of developing an inhibitor of tissue activator plazminogeneza, thereby reducing damage to the cartilage (such as through stimulation of metalloproteinases, and the direct impact on the cartilage).These substances stimulate the synthesis of macromolecules of hyaline cartilage and periodontal tissue, resulting in preventing tooth decay, mediated regulation of the formation of intercellular substance of cartilage macromolecules.
«Piaskledin" should drink 1 capsule daily in the morning during meals.The drug need to drink a large amount of liquid.The time of application is an average of 6 months.If necessary, the doctor can extend the medication or take a second course of therapy."Piaskledin" is contraindicated during pregnancy and lactation, children and adolescents up to 18 years in case of hypersensitivity to the components.The drug is usually well tolerated, but may develop allergic reactions.No cases of overdose have been recorded means.Interactions with other drugs have not been established.