description and the pharmacological action of the drug



"Egilok" - synthetic agent used, in particular, for the treatment of hypertension, migraine prophylaxis.The main active ingredient of this drug is metoprolol tartrate."Egilok" in tablet dosage produced 0.025 g, 0.05 g and 0.1 g in packs of 20, 30, 60,100 tablets.The tablet form of the drug is released and "Egilok Retard" - with the same active compounds and auxiliaries.In a pack of 30 tablets dosage of 0.05 g and 0.1 g

drug is rapidly and almost completely (95 per cent) is absorbed from the gastrointestinal tract.Its bioavailability - 50 percent.During treatment biodostopnusti level is 70 percent.Eating at 20-40 percent increases the bioavailability of the drug.The active substance egilok - metop
rolol - biotransformed in the liver.Metabolites of the drug are not farmakologichno active.95 percent of the active drug substance derived from the body within 72 hours of excretion.Approximately 5 percent of metoprolol remain unchanged.As such, they are eliminated from the body.


Indications



"Egilok" is assigned to patients with hypertension (especially people older than 60 years) using the drug alone or in combination therapy with other antihypertensive agents.Requires reception "egilok" for secondary prevention of myocardial infarction, to prevent strokes, disorders of heart rhythm - ventricular arrhythmia, supraventricular arrhythmia in hyperthyroidism.Prescribe medication for migraine prophylaxis.Also "Egilok" used in coronary heart disease,


Pharmacological action



"Egilok" is a cardioselective beta-blocker, has a hypotensive effect, reduces heart rate, reduce the severity of angina and the frequency of its attacks, it improves the physical condition of the patient.Also, due to the action "egilok" can significantly reduce the risk of another heart attack.It prevents the occurrence of migraine.Subject doses specified in the instruction has no effect on peripheral arteries and bronchial smooth muscle.

maximum effect of the drug is already a half hour after administration.About 5 percent of the active substance excreted in the urine unchanged.The remainder of the drug is biotransformed in the liver.Therefore, people with liver disease, dysfunction of the necessary medical supervision and dosage adjustment.

Dosing and Administration




Dosage "egilok" is assigned to each patient on an individual basis taking into account the state of his health and the presence of accompanying factors.For example, when hypertension initial dose is 50 mg per day in one or two steps.If there is no effect, or insignificant results it is recommended to increase the dosage, but not more than 200 mg per day.For patients with angina pectoris, the recommended dose is 100-200 mg per day of 1 or 2 times per day.The same dose is appointed and supraventricular arrhythmias, as well as arrhythmia.The drug should be taken twice a day (morning and evening).100-200 mg per day twice a day - that is the dosage in the appointment for the secondary prevention of myocardial infarction, migraine.Increasing the dose specified in the abstract, it is not recommended. In patients with diabetes needs to constantly monitor blood sugar levels.

the appointment "egilok" patients with impaired liver and kidney function must be medical supervision.This is necessary due to the ability of the drug to accumulate in the excretory organs.


Contraindications to the use of the drug



"Egilok" should not be given to patients with sinus bradycardia with a heart rate less than 60 beats per minute;AV block second or third degree;sinoatrial blockade;peripheral circulatory disorders;hypotension (low blood pressure below 90-100 mm Hg. v.);High susceptibility of components.In this case, the drug must be replaced with any other means having a similar effect.

Side effects



While receiving "egilok" may appear high fatigue, drowsiness, dizziness, depression, insomnia, poor concentration, nausea, vomiting, diarrhea, constipation, dry mouth, abdominal pain, heart failure.In rare cases may experience blurred vision, tinnitus, conjunctivitis, allergic reactions, skin redness, hair loss, increased sweating, increased body weight.But in most cases the drug is well tolerated. "Egilok" can cause confusion, drowsiness, so it should be used with caution in people whose profession requires special attention.


Cautions



During pregnancy, the use of egilok possible only if the benefit to the mother's body exceeds the risk to the fetus.It should be compulsory monitoring of the fetus.After birth, the newborn will also need monitoring to prevent hypertension, respiratory depression, bradycardia, lower blood sugar levels.During pregnancy "Egilok" recommended to be replaced by a similar drug, but more gentle action.


shelf life and storage conditions




Shelf life - 3 years.
Store at temperatures not above 25 ° C in a dry place, out of reach of children.