«papaverine": pharmacological action
Due to the impact on the smooth muscle of the drug has antispasmodic and vasodilator action.Smooth muscle lined with walls of hollow organs, blood vessels and heart.They directed and the medicine. In high dosages "papaverine" reduces anxiety attack, slowing intracardiac conduction.
drug is prescribed as a remedy for the symptomatic relief of smooth muscle spasms."Papaverine" shows cholecystitis, pilorospazme, spastic colitis, renal colic.It is used for peripheral vascular spasm and cerebral vessels, bronchospasm.In the combined therapy "papaverine" indicated for the treatment of angina.
Do "Papaverine" contra
«papaverine" is contraindicated in atrioventricular heart block, glaucoma, impaired liver function and identify hypersensitivity to the drug.Be wary of those children (
Interaction "Papaverine" with other drugs
Please note that the antispasmodic action "Papaverine" in combination with barbiturates increases.Increased hypotensive effect is possible with the joint use of the drug with tricyclic antidepressants, reserpine, procainamide and quinidine.When smoking efficiency "Papaverine" may decrease.
Method of production "Papaverine" and dosage
«papaverine" is produced in the form of tablets, injectable solutions and rectal suppositories.Injections may be intramuscular, subcutaneous, intravenous (slowly).The last performed only in a hospital under the supervision of a physician. Rectal suppositories are the most convenient in the application to pregnant women to relieve hypertonicity of the uterus.
tablets taken orally 3-4 times a day by 40-60 mg.For children from 6 months to two years, a single dose is 5 mg, 3-4 years - 5-10 mg, 5-6 years - 10 mg, 7-9 years - 10-15 mg, 10-14 - 15-20mg.Subcutaneously and intramuscularly administered 1-2 ml of 2% solution 2-4 times daily, intravenously - 20 mg, with 10-20 ml by dilution in isotonic saline (0.9% sodium chloride solution).Candles used 3-4 times a day.Additional information may be determined by instruction and individual expert advice.
Side effects "Papaverine" should include nausea, constipation, somnolence, hypotension, elevated liver transaminases, eosinophilia, allergic reactions.With rapid intravenous and used in high doses may develop atrioventricular block and cardiac arrhythmias.