main method of conservative treatment of endometriosis is a hormone that is the use of drugs of the following groups: estrogen-progestin, progestins, antiestrogens, gonadotropin inhibitors, agonists gonadotrin-releasing hormone.

Estrogen-progestin preparations

This group of products consists of a combination of synthetic estrogen and progesterone analogues.Oral contraceptives have the following mechanism of therapeutic action: inhibition of the synthesis of gonadotropin-releasing factor, and block production of luteinizing hormone and follicle.The consequence is the formation of anovulatory cycles.Oral contraceptives result in a reduction in the size of the ovaries and changes in their struc
ture.Continuous intake of estrogen-progestin drugs create an artificial menopause and slows down the process of developing the disease.Modern combined estrogen-progestin drugs - "Janine", "Yasmin", "Diane-35".

Progestins Progestins

called pure progestins, which are synthetic compounds similar mechanism of action to the natural progesterone.The mechanism of action of progestins is the binding activity in the target tissues with estrogen and progesterone receptors, which leads to the release of androgen receptors.Funds of this group have a direct antiprogesteronovym and anti-estrogen effect.These include "Duphaston" "promegestone".


Among antiestrogens widespread "Tamoxifen".This drug is a nonsteroidal compound having antagonistic and agonistic activity towards estrogen.The therapeutic effect of "Tamoxifen" due to the blocking of estrogen-dependent receptors and inhibition of prostaglandin synthesis.

inhibitors of gonadotropins

¬ęDanazol" - drugs of this group, contributing to the development of artificial menopause.He is putting antigonadotropnym action, suppresses the production of FSH and luteinizing hormone, the formation of sex hormones in the ovaries.This leads to the binding of androgen and progesterone receptors in the endometrium, and the suppression of the proliferative and secretory activity of the endometrial lesions.

agonists gonadotrin-releasing hormone

synthetic agonist of gonadotropin-releasing hormone are 'Zoladex', 'Sinarel "and" Dekaptil. "They contribute to the development of medical "castration" by blocking the receptors of the anterior pituitary gland and suppressing the production of gonadotropins.Steroidogenesis in the ovaries reduced and their structure and the level of sex hormones correspond postmenopausal.