«Foliber" recommend that women of childbearing age for the prevention of deficiency of vitamin B12 and folic acid in the planning stage of pregnancy (at least a month before conception), as well as for the prevention of neural tube defects in the embryoin the first trimester of pregnancy.Pharmacological action "Folibera" lies in the fact that his method allows to overcome the metabolic blockade was observed in mothers of children with neural tube defects.The nature of the metabolic blockade lies in the metabolism of methionine (indispensable amino acid), in which the vitamin B12 and folic acid are key elements.
Lack of folic acid in a woman's body leads to impaired DNA synthesis in cells, preparing for chromosomal replication and division.This vitamin is involved in the formati
on of nucleic acids and cell division.He also participates as a coenzyme in the synthesis of purines and pyrimidines, this makes it important in the formation of the central nervous system that develops in the fetus at 15-28 days after fertilization.A lack of vitamin B12 leads to similar consequences.The minimum effective daily dose is recommended for healthy women to prevent neural tube defects in the fetus is - 400 mg daily dose of vitamin B12 - 2 mg.
Take the drug on 1 tab.a day before meals.Folic acid is absorbed in the jejunum, its highest concentration in the blood 30-60 minutes after taking the drug.Vitamin B12 can be absorbed in the stomach, its maximum concentration in blood is reached in 8-12 hours. Do not use "Foliber" simultaneously with "methotrexate", because it is a folic acid antagonist.When concomitantly with antiepileptic drugs "Foliber" may reduce their therapeutic effects.Side effects of the drug are allergic reactions.Data on overdose are not available.
«Foliber" is contraindicated in case of hypersensitivity to its components.Precautions should be used drug in violation of suction galactose or glucose, with galactosemia or lactase deficiency."Foliber" does not affect the ability to work with machinery and driving.Keep it in a dry place inaccessible to children at temperature not exceeding 25 ° C.Shelf life funds - 2 years.The drug is available without a prescription.