How to apply "rapamycin" after transplantation
«Rapamycin" is a macrolide antibiotic, it is a product of bacteria Streptomyces hygroscopicus.The active ingredient of the drug - sirolimus.Other names of drugs - "Sirolimus", "Rapamun."The drug has an immunosuppressive effect, but its mechanism of biochemical steps is slightly different from "Tacrolimus" and "Cyclosporin".Means reduces the sensitivity of immune cells to the effects of IL-2.Unlike other drugs of calcineurin inhibitors "Rapamycin" has a low toxicity to the kidney.
are ongoing trials of the drug for the treatment of malignant tumors.There is evidence that sirolimus at renal transplantation in patients with Kaposi's sarcoma has stopped the development of tumors.M
Tablets "Rapamycin" is taken once a day at the same time, during a meal.During treatment, a therapeutic concentration monitoring is carried out of the active substance in the blood.Depending on the change, and change the dose of the drug.During the first 1-2 months, the minimum concentration of active substance in the blood should be 4-12 ng / ml in blood, while the introduction of "Ciclosporin" (its concentration should be 150-400 ng / ml).After the cancellation of "Ciclosporin" maintenance therapy for a minimum concentration of sirolimus in the blood should be 12-20 ng / ml.
«Rapamycin": side effects, contraindications
main side effects of "Rapamutsina" are: aggravation of various infections, impaired wound healing lymphocele, edema, acute hepatotoxicity.During supplementation may increase cholesterol levels in the blood and triglitserilov over time the effect runs.There is also reducing the number of platelet cells in the blood.Side effects disappear or become less pronounced with decreasing dosage.The drug is contraindicated in pregnancy and lactation, in children and adolescents up to 18 years.