How to apply "Diferelin»
«Diferelin" prescribed in the following indications: genital and extragenital endometriosis, hyperplastic processes in the endometrium, endometrial cysts, premature onset of reproductive age in children, uterine fibroids, prostate tumor, breast tumor.For the treatment of female infertility drug use with gonadotropins in order to create artificial conditions of ovulation.
release agent in the form of a lyophilizate for the manufacture of a solution in various concentrations."Diferelin" (0.1 pl) was used for subcutaneous injection.For ovarian stimulation injections do, starting from the 2nd day of the cycle and ending 1 day prior to administration of human chorionic gonadotropin.Course application is from 10 to 12 days.
«Diferelin" (3.75 mg) was used for intramuscular injection.In prostate cancer drug is administered in an amount of 3
injections for the treatment of endometriosis "Diferelin" needs to be done in the first 5 days of the cycle in the monthly amount of 3.75 mg.Injections are made every 4 weeks.Duration of treatment - no longer than 6 months.For the treatment of female infertility drug is administered on the second day of the cycle in an amount of 3.75 mg.When uterine fibroids "Diferelin" used in the first 5 days of menstruation cycle.Repeat injections every 4 weeks in an amount of 3.75 mg.Course duration - 3 months.
Side effects, contraindications to the use of "Diferelin»
Adverse action "Diferelin" refers ovarian hyperstimulation, accompanied by increases in size, abdominal pain.In the period of treatment can be observed flushes, decreased libido, depression, fatigue, fever, dysmenorrhea, allergic reactions (rash, urticaria, pruritus, angioedema).In rare cases there are vomiting, nausea, weight gain, increased blood pressure, blurred vision, headache, muscle and joint pain.
Men sometimes a decrease in potency, ureteral obstruction, elevated plasma levels of acid phosphatase.Prolonged use of "Diferelin" can provoke hypogonadotropic amenorrhea.The drug is contraindicated in case of hypersensitivity to its components, during pregnancy and lactation.